G-quadruplexesorG4-DNAisaDNAstructuralmotifthatisconsideredtobefunctionallyimportantinthemammaliangenomefortranscriptionalregulation,DNAreplicationandgenomest
ABIlityarenucleicacid.Thesenucleicacidsequencesthatarerichinguanineandarecapableofformingafour-strandedstructure.FourguaninebasescanassociatethroughHoogsteenbasepairingandarecharacterizedbyvariablestacksofguaninequartetplanes,strandorientation,glycosidicbondanglesandstabilizingcations.Itmayserveimportantregulatoryandstructuralfunctions;inaddition,itcanbethesourceofgenomicinstabilitywhichmayleadtocancer,agingandhumangeneticdiseases