Tauopathiesareagroupofdiversedementiasandmovementdisorderswhichhaveacommonpathologicalfeatureinthattheyalldisplaythepresenceofintracellularaccumulationofabnormalfilamentsoftauprotein.Fur
Thermore,theseaccumulatedtauproteinsalldisplayanabnormalphosphorylationpatternthatmaybediseasespecific.Asanexample,Amyotrophiclateralsclerosis(ALS,alsoreferredtoasCharcot"sdiseaseorLouGehrig"sdisease)isthemostcommonformofprogressivemotorneurondiseaseinNorthAmerica.ALSgraduallydisablesthepatient"svoluntarymotormusclecontroluntilitbecomesfatal.