Thestemcellleukemia(SCL)protein(alsoknownasTcellAcuteLymphocyticLeukemia1Protein(TAL1))isahematopoietic-specifictranscriptionfactorofthebasichelix-loop-helix(bHLH)family.SCLisexpressedinhematopoieticstemcells,aswellasmultipotent,erythroid,andmegakaryocytic
Progenitors;itisessentialfortheregulationofhematopoiesisandalsoregulatesangiogenesisanderythrocytematuration.InpatientswithT-cellacutelymphoblasticleukemia(T-ALL),theSCLgeneisthemostfrequenttargetofchromosomalrearrangementswithanirregularactivationofthistranscriptionfactorinvolvedin60%ofT-ALLcases,whichindicatesthatabnormalregulationofSCL"sactivitymayleadtothedevelopmentofTcellleukemia.